PGC-1α-mediated imbalance of mitochondria-lipid droplet homeostasis in neomycin-induced ototoxicity and nephrotoxicity

• Main Authors: Bin Chen (Author), Cheng Cheng (Author), Yunhao Wu (Author), Siyu Li (Author), Mo Han (Author), Le Zhen (Author), Ying Peng (Author), Suhan Guo (Author), Kaidi Shen (Author), Xia Gao (Author), Renjie Chai (Author), Guangji Wang (Author), Fang Zhou (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ototoxicity and nephrotoxicity are the most prevalent side effects of aminoglycoside antibiotics (gentamicin, amikacin, neomycin) and platinum anti-tumor drugs (cisplatin, carboplatin). The inner ear and kidney share similarities in drug deposition and toxicity, but the underlying pathophysiological...