MicroRNAs 143 and 150 in whole blood enable detection of T-cell immunoparalysis in sepsis

• Main Authors: P Möhnle (Author), S Hirschberger (Author), L C Hinske (Author), J Briegel (Author), M Hübner (Author), S Weis (Author), G Dimopoulos (Author), M Bauer (Author), E J Giamarellos-Bourboulis (Author), S Kreth (Author)
• Format: Book
• Published: BMC, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Currently, no suitable clinical marker for detection of septic immunosuppression is available. We aimed at identifying microRNAs that could serve as biomarkers of T-cell mediated immunoparalysis in sepsis. Methods RNA was isolated from purified T-cells or from whole blood cells o...