Population Pharmacokinetics of Intravenous Acyclovir in Oncologic Pediatric Patients

• Main Authors: Natalia Maximova (Author), Daniela Nisticò (Author), Giacomo Luci (Author), Roberto Simeone (Author), Elisa Piscianz (Author), Ludovica Segat (Author), Egidio Barbi (Author), Antonello Di Paolo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Acyclovir represents the first-line prophylaxis and therapy for herpes virus infections. However, its pharmacokinetics in children exposes them to the risk of ineffective or toxic concentrations. The study was aimed at investigating the population pharmacokinetics (POP/PK) of intravenous...