Enhancing Dissolution and Oral Bioavailability of Ursodeoxycholic Acid with a Spray-Dried pH-Modified Extended Release Formulation

• Main Authors: Jaehyeok Lee (Author), Chul Haeng Lee (Author), Jong-Geon Lee (Author), So Yeon Jeon (Author), Min-Koo Choi (Author), Im-Sook Song (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ursodeoxycholate (UDCA) has low oral bioavailability and pH-dependent solubility and permeability. Thus, we developed a pH-modified extended-release formulation of UDCA using Na₂CO₃ as the alkalizing agent and hydroxypropyl methylcellulose (HPMC) as the...