Hepatic signal transducer and activator of transcription‐3 signalling drives early‐stage pancreatic cancer cachexia via suppressed ketogenesis

• Main Authors: Paige C. Arneson‐Wissink (Author), Heike Mendez (Author), Katherine Pelz (Author), Jessica Dickie (Author), Alexandra Q. Bartlett (Author), Beth L. Worley (Author), Stephanie M. Krasnow (Author), Robert Eil (Author), Aaron J. Grossberg (Author)
• Format: Book
• Published: Wiley, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Patients with pancreatic ductal adenocarcinoma (PDAC) often suffer from cachexia, a wasting syndrome that significantly reduces both quality of life and survival. Although advanced cachexia is associated with inflammatory signalling and elevated muscle catabolism, the early event...