Neutropenic Mice Provide Insight into the Role of Skin-Infiltrating Neutrophils in the Host Protective Immunity against Filarial Infective Larvae.

• Main Authors: Nicolas Pionnier (Author), Emilie Brotin (Author), Gregory Karadjian (Author), Patrice Hemon (Author), Françoise Gaudin-Nomé (Author), Nathaly Vallarino-Lhermitte (Author), Adélaïde Nieguitsila (Author), Frédéric Fercoq (Author), Marie-Laure Aknin (Author), Viviana Marin-Esteban (Author), Sylvie Chollet-Martin (Author), Géraldine Schlecht-Louf (Author), Françoise Bachelerie (Author), Coralie Martin (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our knowledge and control of the pathogenesis induced by the filariae remain limited due to experimental obstacles presented by parasitic nematode biology and the lack of selective prophylactic or curative drugs. Here we thought to investigate the role of neutrophils in the host innate immune respon...