Tumor BRCA testing can reveal a high tumor mutational burden related to POLE pathogenic variants

• मुख्य लेखकों: M.-C. Villy (लेखक), J. Masliah-Planchon (लेखक), S. Melaabi (लेखक), O. Trabelsi Grati (लेखक), E. Girard (लेखक), G. Bataillon (लेखक), A. Vincent-Salomon (लेखक), J. Le Gall (लेखक), L. Golmard (लेखक), D. Stoppa-Lyonnet (लेखक), I. Bieche (लेखक), C. Colas (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2021-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: Tumors harboring a POLE pathogenic variant, associated with high tumor mutational burden, are good candidates for immunotherapy. However, POLE pathogenic variants are not currently screened in routine clinical practice. Can these tumors be identified by means of an already available test?...