Tumor BRCA testing can reveal a high tumor mutational burden related to POLE pathogenic variants

Tumor BRCA testing can reveal a high tumor mutational burden related to POLE pathogenic variants

Objective: Tumors harboring a POLE pathogenic variant, associated with high tumor mutational burden, are good candidates for immunotherapy. However, POLE pathogenic variants are not currently screened in routine clinical practice. Can these tumors be identified by means of an already available test?...

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Main Authors: M.-C. Villy (Author), J. Masliah-Planchon (Author), S. Melaabi (Author), O. Trabelsi Grati (Author), E. Girard (Author), G. Bataillon (Author), A. Vincent-Salomon (Author), J. Le Gall (Author), L. Golmard (Author), D. Stoppa-Lyonnet (Author), I. Bieche (Author), C. Colas (Author)
Format: Book
Published: Elsevier, 2021-08-01T00:00:00Z.
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3rd Floor Main Library

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