Population Pharmacokinetics and Exposure-Response of Luspatercept, an Erythroid Maturation Agent, in Anemic Patients With Myelodysplastic Syndromes

• Main Authors: Nianhang Chen (Author), Nastya Kassir (Author), Abderrahmane Laadem (Author), Stephen E. Maxwell (Author), Priya Sriraman (Author), Ana Carolina Giuseppi (Author), Steve Ritland (Author), Peter G. Linde (Author), Balasubrahmanyam Budda (Author), Joseph G. Reynolds (Author), Simon Zhou (Author), Maria Palmisano (Author)
• Format: Book
• Published: Wiley, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Luspatercept is a recombinant fusion protein that enhances late‐stage erythroid maturation. This report describes the population pharmacokinetics and exposure-response relationship of luspatercept in 260 patients with anemia due to myelodysplastic syndromes. Luspatercept displayed linear and time‐in...