KCa3.1 inhibition-induced activation of the JNK/c-Jun signaling pathway enhances IL-10 expression in peripherally-induced regulatory T cells

• Autori principali: Miki Matsui (Autore), Junko Kajikuri (Autore), Kyoko Endo (Autore), Hiroaki Kito (Autore), Susumu Ohya (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2022-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The KCa3.1 inhibition up-regulates IL-10 expression in regulatory T (Treg) cells in the recovery phase of inflammatory bowel disease (IBD) model mice; however, the underlying signaling pathway remains unclear. We investigated the involvement of AP-1 (Fos/Jun) and NF-κB in the expression of IL-10 and...