KCa3.1 inhibition-induced activation of the JNK/c-Jun signaling pathway enhances IL-10 expression in peripherally-induced regulatory T cells

The KCa3.1 inhibition up-regulates IL-10 expression in regulatory T (Treg) cells in the recovery phase of inflammatory bowel disease (IBD) model mice; however, the underlying signaling pathway remains unclear. We investigated the involvement of AP-1 (Fos/Jun) and NF-κB in the expression of IL-10 and...

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Main Authors: Miki Matsui (Author), Junko Kajikuri (Author), Kyoko Endo (Author), Hiroaki Kito (Author), Susumu Ohya (Author)
Format: Book
Published: Elsevier, 2022-01-01T00:00:00Z.
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