Detection of Synergistic Interaction on an Additive Scale Between Two Drugs on Abnormal Elevation of Serum Alanine Aminotransferase Using Machine-Learning Algorithms

• Autors principals: Hayato Akimoto (Autor), Takuya Nagashima (Autor), Kimino Minagawa (Autor), Takashi Hayakawa (Autor), Yasuo Takahashi (Autor), Satoshi Asai (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Drug-induced liver injury (DILI) is a common adverse drug reaction, with abnormal elevation of serum alanine aminotransferase (ALT). Several clinical studies have investigated whether a combination of two drugs alters the reporting frequency of DILI using traditional statistical methods such as mult...