Uncovering the Genomic Landscape in Newly Diagnosed and Relapsed Pediatric Cytogenetically Normal FLT3‐ITD AML

• Главные авторы: Daelynn R. Buelow (Автор), Stanley B. Pounds (Автор), Yong‐Dong Wang (Автор), Lei Shi (Автор), Yongjin Li (Автор), David Finkelstein (Автор), Sheila Shurtleff (Автор), Geoffrey Neale (Автор), Hiroto Inaba (Автор), Raul C. Ribeiro (Автор), Reid Palumbo (Автор), Dominique Garrison (Автор), Shelley J. Orwick (Автор), James S. Blachly (Автор), Karl Kroll (Автор), John C. Byrd (Автор), Tanja A. Gruber (Автор), Jeffrey E. Rubnitz (Автор), Sharyn D. Baker (Автор)
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• Опубликовано: Wiley, 2019-11-01T00:00:00Z.
• Предметы: article
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Fms‐like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutations, common in pediatric acute myeloid leukemia (AML), associate with early relapse and poor prognosis. Past studies have suggested additional cooperative mutations are required for leukemogenesis in FLT3‐ITD+ AML. Using RNA s...