Uncovering the Genomic Landscape in Newly Diagnosed and Relapsed Pediatric Cytogenetically Normal FLT3‐ITD AML

• Main Authors: Daelynn R. Buelow (Author), Stanley B. Pounds (Author), Yong‐Dong Wang (Author), Lei Shi (Author), Yongjin Li (Author), David Finkelstein (Author), Sheila Shurtleff (Author), Geoffrey Neale (Author), Hiroto Inaba (Author), Raul C. Ribeiro (Author), Reid Palumbo (Author), Dominique Garrison (Author), Shelley J. Orwick (Author), James S. Blachly (Author), Karl Kroll (Author), John C. Byrd (Author), Tanja A. Gruber (Author), Jeffrey E. Rubnitz (Author), Sharyn D. Baker (Author)
• Format: Book
• Published: Wiley, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fms‐like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutations, common in pediatric acute myeloid leukemia (AML), associate with early relapse and poor prognosis. Past studies have suggested additional cooperative mutations are required for leukemogenesis in FLT3‐ITD+ AML. Using RNA s...