Effects of Simvastatin on Pharmacokinetics and Anticoagulant Effects of Dabigatran in Healthy Subjects

• Главные авторы: Hyewon Chung (Автор), Jong-Min Kim (Автор), Jin-Woo Park (Автор), Jihyeon Noh (Автор), Kyoung-Ah Kim (Автор), Ji-Young Park (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2023-02-01T00:00:00Z.
• Предметы: article
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Higher risk of major hemorrhage associated with concomitant use of dabigatran and simvastatin compared to other statins was previously reported with a suggestion of P-glycoprotein-mediated interaction. The aim of this study was to evaluate the effects of simvastatin on pharmacokinetics and anticoagu...