Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (−)‐noradrenaline

• Main Authors: Alexander Dashwood (Author), Elizabeth Cheesman (Author), Yee Weng Wong (Author), Haris Haqqani (Author), Nicole Beard (Author), Karen Hay (Author), Melanie Spratt (Author), Wandy Chan (Author), Peter Molenaar (Author)
• Format: Book
• Published: Wiley, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Omecamtiv mecarbil (OM) is a novel medicine for systolic heart failure, targeting myosin to enhance cardiomyocyte performance. To assist translation to clinical practice we investigated OMs effect on explanted human failing hearts, specifically; contractile dynamics, interaction with the β1...