Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (−)‐noradrenaline

• Autori principali: Alexander Dashwood (Autore), Elizabeth Cheesman (Autore), Yee Weng Wong (Autore), Haris Haqqani (Autore), Nicole Beard (Autore), Karen Hay (Autore), Melanie Spratt (Autore), Wandy Chan (Autore), Peter Molenaar (Autore)
• Natura: Libro
• Pubblicazione: Wiley, 2021-05-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Omecamtiv mecarbil (OM) is a novel medicine for systolic heart failure, targeting myosin to enhance cardiomyocyte performance. To assist translation to clinical practice we investigated OMs effect on explanted human failing hearts, specifically; contractile dynamics, interaction with the β1...