Association between CYP2D6 Genotypes and the Risk of Antidepressant Discontinuation, Dosage Modification and the Occurrence of Maternal Depression during Pregnancy

• Main Authors: Anick Bérard (Author), Andrea Gaedigk (Author), Odile Sheehy (Author), Christina Chambers (Author), Mark Roth (Author), Pina Bozzo (Author), Diana Johnson (Author), Kelly Kao (Author), Sharon Lavigne (Author), Lori Wolfe (Author), Dee Quinn (Author), Kristen Dieter (Author), Jin-Ping Zhao (Author), the OTIS (MotherToBaby) (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Importance: Polymorphic expression of drug metabolizing enzymes affects the metabolism of antidepressants, and thus can contribute to drug response and/or adverse events. Pregnancy itself can affect CYP2D6 activity with profound variations determined by CYP2D6 genotype.Objective: To investigate the...