Prediction of antipsychotics efficacy based on a polygenic risk score: a real-world cohort study

• Main Authors: Marco De Pieri (Author), Marco Ferrari (Author), Giorgio Pistis (Author), Franziska Gamma (Author), Franca Marino (Author), Armin Von Gunten (Author), Philippe Conus (Author), Marco Cosentino (Author), Chin-Bin Eap (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Response to antipsychotics is subject to a wide interindividual variability, due to genetic and non-genetic factors. Several single nucleotide polymorphisms (SNPs) have been associated with response to antipsychotics in genome-wide association studies (GWAS). Polygenic risk scores (PRS)...