Nucleolin-aptamer therapy in retinoblastoma: molecular changes and mass spectrometry-based imaging

• Main Authors: Nithya Subramanian (Author), Amitava Srimany (Author), Jagat R Kanwar (Author), Rupinder K Kanwar (Author), Balachandran Akilandeswari (Author), Pukhraj Rishi (Author), Vikas Khetan (Author), Madavan Vasudevan (Author), Thalappil Pradeep (Author), Subramanian Krishnakumar (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Retinoblastoma (RB) is an intraocular childhood tumor which, if left untreated, leads to blindness and mortality. Nucleolin (NCL) protein which is differentially expressed on the tumor cell surface, binds ligands and regulates carcinogenesis and angiogenesis. We found that NCL is over expressed in R...