Elucidation of the Differences in Cinobufotalin's Pharmacokinetics Between Normal and Diethylnitrosamine-Injured Rats: The Role of P-Glycoprotein

• Main Authors: Xiaojing Zhang (Author), Tong Liu (Author), Yidan Zhang (Author), Fanye Liu (Author), Haiying Li (Author), Dong Fang (Author), Chaojie Wang (Author), Hua Sun (Author), Songqiang Xie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cinobufotalin is one of the major anti-tumor components isolated from toad venom and has been used in the clinical therapy of hepatocellular carcinoma (HCC), known as Cinobufacini injection. However, the pharmacokinetic (PK) behaviors of cinobufotalin in vivo with HCC are still unknown. Hence, we ha...