Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration

• المؤلفون الرئيسيون: Xiaobo Nie (مؤلف), Fulin Xia (مؤلف), Ying Liu (مؤلف), Yun Zhou (مؤلف), Wenling Ye (مؤلف), Panha Hean (مؤلف), Jiming Meng (مؤلف), Huiyang Liu (مؤلف), Lei Liu (مؤلف), Jianxun Wen (مؤلف), Xuequn Ren (مؤلف), Wei-Dong Chen (مؤلف), Yan-Dong Wang (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The aberrant expression of Wnt3 has linked to several types of human malignancies. However, it is not known for its role in tumorigenesis of colorectal cancer (CRC). Herein, we show that Wnt3 is upregulated in human CRC tissues and is essential for the CRC progression. Knockdown of Wnt3 in human CRC...