Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration

• Main Authors: Xiaobo Nie (Author), Fulin Xia (Author), Ying Liu (Author), Yun Zhou (Author), Wenling Ye (Author), Panha Hean (Author), Jiming Meng (Author), Huiyang Liu (Author), Lei Liu (Author), Jianxun Wen (Author), Xuequn Ren (Author), Wei-Dong Chen (Author), Yan-Dong Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aberrant expression of Wnt3 has linked to several types of human malignancies. However, it is not known for its role in tumorigenesis of colorectal cancer (CRC). Herein, we show that Wnt3 is upregulated in human CRC tissues and is essential for the CRC progression. Knockdown of Wnt3 in human CRC...