Chrysin-based supramolecular cyclodextrin-calixarene drug delivery system: a novel approach for attenuating cardiac fibrosis in chronic diabetes

• Main Authors: Maria Consiglia Trotta (Author), Hildegard Herman (Author), Alina Ciceu (Author), Bianca Mladin (Author), Marcel Rosu (Author), Caterina Claudia Lepre (Author), Marina Russo (Author), Ildikó Bácskay (Author), Ferenc Fenyvesi (Author), Raffaele Marfella (Author), Anca Hermenean (Author), Cornel Balta (Author), Michele D'Amico (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Cardiac fibrosis is strongly induced by diabetic conditions. Both chrysin (CHR) and calixarene OTX008, a specific inhibitor of galectin 1 (Gal-1), seem able to reduce transforming growth factor beta (TGF-β)/SMAD pro-fibrotic pathways, but their use is limited to their low solubility. T...