Total and Free Blood and Plasma Concentration Changes in Pregnancy for Medicines Highly Bound to Plasma Proteins: Application of Physiologically Based Pharmacokinetic Modelling to Understand the Impact on Efficacy

• 主要な著者: Paola Coppola (著者), Andrew Butler (著者), Susan Cole (著者), Essam Kerwash (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2023-10-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Free drug concentrations are generally considered the pharmacologically active moiety and are important for cellular diffusion and distribution. Pregnancy-related changes in plasma protein binding and blood partitioning are due to decreases in plasma albumin, alpha-1-acid glycoprotein, and haematocr...