Effects of pharmacological inhibition of the sodium‐dependent phosphate cotransporter 2b (NPT2b) on intestinal phosphate absorption in mouse and rat models

• Main Authors: Xiaojun Wang (Author), Yanping Xu (Author), Xiaohong Yu (Author), Asim Dey (Author), Hong Y. Zhang (Author), Charity M. Zink (Author), Derek Wodka (Author), Gina Porter (Author), William F. Matter (Author), Leah Porras (Author), Charles A. Reidy (Author), Jeffrey A. Peterson (Author), Brian E. Mattioni (Author), Joseph V. Haas (Author), Mark C. Kowala (Author), John R. Wetterau (Author)
• Format: Book
• Published: Wiley, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract An excess phosphate burden in renal disease has pathological consequences for bone, kidney, and heart. Therapies to decrease intestinal phosphate absorption have been used to address the problem, but with limited success. Here, we describe the in vivo effects of a novel potent inhibitor of...