Effects of pharmacological inhibition of the sodium‐dependent phosphate cotransporter 2b (NPT2b) on intestinal phosphate absorption in mouse and rat models

• मुख्य लेखकों: Xiaojun Wang (लेखक), Yanping Xu (लेखक), Xiaohong Yu (लेखक), Asim Dey (लेखक), Hong Y. Zhang (लेखक), Charity M. Zink (लेखक), Derek Wodka (लेखक), Gina Porter (लेखक), William F. Matter (लेखक), Leah Porras (लेखक), Charles A. Reidy (लेखक), Jeffrey A. Peterson (लेखक), Brian E. Mattioni (लेखक), Joseph V. Haas (लेखक), Mark C. Kowala (लेखक), John R. Wetterau (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2022-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract An excess phosphate burden in renal disease has pathological consequences for bone, kidney, and heart. Therapies to decrease intestinal phosphate absorption have been used to address the problem, but with limited success. Here, we describe the in vivo effects of a novel potent inhibitor of...