Screening for Susceptibility-Related Biomarkers of Diclofenac-Induced Liver Injury in Rats Using Metabolomics

• Main Authors: Can Tu (Author), Yuan Gao (Author), Di Song (Author), Ming Niu (Author), Run-ran Ma (Author), Ming-xi Zhou (Author), Xian He (Author), Xiao-he Xiao (Author), Jia-bo Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Early identification of individuals susceptible to idiosyncratic drug-induced liver injury (IDILI) is a challenging unmet demand. Diclofenac, one of the most widely available over-the-counter drugs for pain management worldwide, may induce liver dysfunction, acute liver failure, and death. Herein, w...