From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib

• Үндсэн зохиолчид: Amal Kamal Abdel-Aziz (Зохиогч), Ashraf B. Abdel-Naim (Зохиогч), Samia Shouman (Зохиогч), Saverio Minucci (Зохиогч), Mohamed Elgendy (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Frontiers Media S.A., 2017-10-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Sunitinib, a multityrosine kinase inhibitor, is currently the standard first-line therapy in metastatic renal cell carcinoma (mRCC) and is also used in treating patients with pancreatic neuroendocrine and imatinib-resistant gastrointestinal stromal tumors (GIST). Nevertheless, most patients eventual...