Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells

• Main Authors: Weisin Chen (Author), Miersalijiang Yasen (Author), Hanquan Wang (Author), Chenyang Zhuang (Author), Zixiang Wang (Author), Shunyi Lu (Author), Libo Jiang (Author), Hong Lin (Author)
• Format: Book
• Published: BMC, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Intervertebral disc degeneration results from a variety of etiologies, including inflammation and aging. Degenerated intervertebral discs feature down-regulated extracellular matrix synthesis, resulting in losing their ability to retain water and absorb compression. Celecoxib is...