The epigenetic signatures of opioid addiction and physical dependence are prevented by D-cysteine ethyl ester and betaine

• Asıl Yazarlar: Jennifer McDonough (Yazar), Naveen K. Singhal (Yazar), Paulina M. Getsy (Yazar), Katherine Knies (Yazar), Zackery T. Knauss (Yazar), Devin Mueller (Yazar), James N. Bates (Yazar), Derek S. Damron (Yazar), Stephen J. Lewis (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

We have reported that D,L-thiol esters, including D-cysteine ethyl ester (D-CYSee), are effective at overcoming opioid-induced respiratory depression (OIRD) in rats. Our on-going studies reveal that co-injections of D-CYSee with multi-day morphine injections markedly diminish spontaneous withdrawal...