The epigenetic signatures of opioid addiction and physical dependence are prevented by D-cysteine ethyl ester and betaine

• Main Authors: Jennifer McDonough (Author), Naveen K. Singhal (Author), Paulina M. Getsy (Author), Katherine Knies (Author), Zackery T. Knauss (Author), Devin Mueller (Author), James N. Bates (Author), Derek S. Damron (Author), Stephen J. Lewis (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have reported that D,L-thiol esters, including D-cysteine ethyl ester (D-CYSee), are effective at overcoming opioid-induced respiratory depression (OIRD) in rats. Our on-going studies reveal that co-injections of D-CYSee with multi-day morphine injections markedly diminish spontaneous withdrawal...