Discovery of New 1,4,6-Trisubstituted-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridines with Anti-Tumor Efficacy in Mouse Model of Breast Cancer

• Main Authors: Maria Georgiou (Author), Nikolaos Lougiakis (Author), Roxane Tenta (Author), Katerina Gioti (Author), Stavroula Baritaki (Author), Lydia-Evangelia Gkaralea (Author), Elisavet Deligianni (Author), Panagiotis Marakos (Author), Nicole Pouli (Author), Dimitris Stellas (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purine analogues are important therapeutic tools due to their affinity to enzymes or receptors that are involved in critical biological processes. In this study, new 1,4,6-trisubstituted pyrazolo[3,4-<i>b</i>]pyridines were designed and synthesized, and their cytotoxic potential was been...