Multi-shell gold nanoparticles functionalized with methotrexate: a novel nanotherapeutic approach for improved antitumoral and antioxidant activity and enhanced biocompatibility

• Main Authors: Denisse-Iulia Bostiog (Author), Natalia Simionescu (Author), Adina Coroaba (Author), Ioana C. Marinas (Author), Mariana C. Chifiriuc (Author), Gratiela Gradisteanu Pircalabioru (Author), Stelian S. Maier (Author), Mariana Pinteala (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Methotrexate (MTX) is a folic acid antagonist routinely used in cancer treatment, characterized by poor water solubility and low skin permeability. These issues could be mitigated by using drug delivery systems, such as functionalized gold nanoparticles (AuNPs), known for their versatility and uniqu...