Dexamethasone prevents interleukin-1β-induced nuclear factor-κB activation by upregulating IκB-α synthesis, in lymphoblastic cells
Aims: Glucocorticoids (GCs) exert some of their anti-inflammatory actions by preventing the activation of the transcription factor nuclear factor (NF)-κB. The GC-dependent inhibition of NF-κB may occur at different levels, but the mechanisms involved are still incompletely understood. In this work,...
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| Main Authors: | , , , , |
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| Format: | Book |
| Published: |
Hindawi Limited,
2003-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Aims: Glucocorticoids (GCs) exert some of their anti-inflammatory actions by preventing the activation of the transcription factor nuclear factor (NF)-κB. The GC-dependent inhibition of NF-κB may occur at different levels, but the mechanisms involved are still incompletely understood. In this work, we investigated whether the synthetic GC, dexamethasone (Dex), modulates the activity of NF-κB in the lymphoblastic CCRF-CEM cell line. We also evaluated the ability of Dex to prevent the activation of NF-κB in response to the potent proinflammatory cytokine, interleukin (IL)-1β. |
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| Item Description: | 0962-9351 1466-1861 10.1080/0962935031000096953 |