Health economic analysis of polygenic risk score use in primary prevention of coronary artery disease - A system dynamics model

• Main Authors: Stephen T. Vernon (Author), Stuart Brentnall (Author), Danielle J Currie (Author), Cindy Peng (Author), Michael P. Gray (Author), Giordano Botta (Author), Deo Mujwara (Author), Stephen J. Nicholls (Author), Stuart M. Grieve (Author), Julie Redfern (Author), Clara Chow (Author), Jean-Frederic Levesque (Author), Peter J. Meikle (Author), Garry Jennings (Author), Zanfina Ademi (Author), Andrew Wilson (Author), Gemma A. Figtree (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Primary prevention programs utilising traditional risk scores fail to identify all individuals who suffer acute cardiovascular events. We aimed to model the impact and cost effectiveness of incorporating a Polygenic risk scores (PRS) into the cardiovascular disease CVD primary prevention...