Synthesis and Neuroprotective Action of Optically Pure Neoechinulin A and Its Analogs

Synthesis and Neuroprotective Action of Optically Pure Neoechinulin A and Its Analogs

We developed an efficient, stereoselective synthetic method for the diketopiperazine moiety of neoechinulin A and its derivatives. The intramolecular cyclization at 80 ºC proceeded with minimal racemization of the stereogenic center at C-12 on neoechinulin A, even though the cyclization at 110 ºC ca...

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Main Authors: Toshiaki Aoki (Author), Kensuke Ohnishi (Author), Masaaki Kimoto (Author), Satoshi Fujieda (Author), Kouji Kuramochi (Author), Toshifumi Takeuchi (Author), Atsuo Nakazaki (Author), Nobuo Watanabe (Author), Fumio Sugawara (Author), Takao Arai (Author), Susumu Kobayashi (Author)
Format: Book
Published: MDPI AG, 2010-03-01T00:00:00Z.
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3rd Floor Main Library

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