Tamoxifen Inhibits Cardiac ATP-Sensitive and Acetylcholine-Activated K+ Currents in Part by Interfering With Phosphatidylinositol 4,5-Bisphosphate-Channel Interaction

• Hlavní autoři: Daniela Ponce-Balbuena (Autor), Eloy G. Moreno-Galindo (Autor), Angélica López-Izquierdo (Autor), Tania Ferrer (Autor), José A. Sánchez-Chapula (Autor)
• Médium: Kniha
• Vydáno: Elsevier, 2010-01-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Tamoxifen inhibits transmembrane currents of the Kir2.x inward rectifier potassium channels by interfering with the interaction of the channels with membrane phosphatidylinositol 4,5-bisphosphate (PIP2). We tested the hypothesis that Kir channels with low affinity for PIP2, like the adenosine tripho...