Separation of atropisomers by chiral liquid chromatography and thermodynamic analysis of separation mechanism

In the pharmaceutical industry, the analysis of atropisomers is of considerable interest from a scientific and regulatory perspective. The compound of interest contains two stereogenic axes due to the hindered rotation around the single bonds connecting the aryl groups, which results in four potenti...

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Main Authors: Ling Zhang (Author), Yue Hu (Author), Elizabeth Galella (Author), Frank P. Tomasella (Author), William P. Fish (Author)
Format: Book
Published: Elsevier, 2017-06-01T00:00:00Z.
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