Inhibition of catechol-O-methyltransferase by natural pentacyclic triterpenes: structure-activity relationships and kinetic mechanism

• Main Authors: Fang-Yuan Wang (Author), Gui-Lin Wei (Author), Yu-Fan Fan (Author), Dong-Fang Zhao (Author), Ping Wang (Author), Li-Wei Zou (Author), Ling Yang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibitors of COMT are clinically used for the treatment of Parkinson's disease. Here, we report the first natural pentacyclic triterpenoid-type COMT inhibitors and their structure-activity relationships and inhibition mechanism. The most potent compounds were found to be oleanic acid, betulini...