Radiosynthesis and Preclinical Evaluation of an ¹⁸F-Labeled Triazolopyridopyrazine-Based Inhibitor for Neuroimaging of the Phosphodiesterase 2A (PDE2A)

• Main Authors: Barbara Wenzel (Author), Stefan R. Fritzsche (Author), Magali Toussaint (Author), Detlef Briel (Author), Klaus Kopka (Author), Peter Brust (Author), Matthias Scheunemann (Author), Winnie Deuther-Conrad (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cyclic nucleotide phosphodiesterase 2A is an intracellular enzyme which hydrolyzes the secondary messengers cAMP and cGMP and therefore plays an important role in signaling cascades. A high expression in distinct brain areas as well as in cancer cells makes PDE2A an interesting therapeutic and d...