Nuclear p120-catenin regulates the anoikis resistance of mouse lobular breast cancer cells through Kaiso-dependent Wnt11 expression

• Main Authors: Robert A. H. van de Ven (Author), Milou Tenhagen (Author), Wouter Meuleman (Author), Jeske J. G. van Riel (Author), Ron C. J. Schackmann (Author), Patrick W. B. Derksen (Author)
• Format: Book
• Published: The Company of Biologists, 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

E-cadherin inactivation underpins the progression of invasive lobular breast carcinoma (ILC). In ILC, p120-catenin (p120) translocates to the cytosol where it controls anchorage independence through the Rho-Rock signaling pathway, a key mechanism driving tumor growth and metastasis. We now demonstra...