A Novel UHPLC-MS/MS Method for the Quantification of Seven Opioids in Different Human Tissues

• Main Authors: Alessandra Manca (Author), Amedeo De Nicolò (Author), Elisa Delia De Vivo (Author), Micol Ferrara (Author), Sharon Oh (Author), Sahar Khalili (Author), Niamh Higgins (Author), Robert G. Deiss (Author), Stefano Bonora (Author), Jessica Cusato (Author), Alice Palermiti (Author), Jacopo Mula (Author), Sara Gianella (Author), Antonio D'Avolio (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Opioids are considered the cornerstone of pain management: they show good efficacy as a first-line therapy for moderate to severe cancer pain. Since pharmacokinetic/pharmacodynamic information about the tissue-specific effect and toxicity of opioids is still scarce, their quantification...