Sigma Receptors as Endoplasmic Reticulum Stress "Gatekeepers" and their Modulators as Emerging New Weapons in the Fight Against Cancer

• Main Authors: Anna Tesei (Author), Michela Cortesi (Author), Alice Zamagni (Author), Chiara Arienti (Author), Sara Pignatta (Author), Michele Zanoni (Author), Mayra Paolillo (Author), Daniela Curti (Author), Marta Rui (Author), Daniela Rossi (Author), Simona Collina (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite the interest aroused by sigma receptors (SRs) in the area of oncology, their role in tumor biology remains enigmatic. The predominant subcellular localization and main site of activity of SRs are the endoplasmic reticulum (ER). Current literature data, including recent findings on the sigma...