Novel bi-allelic MSH4 variants causes meiotic arrest and non-obstructive azoospermia

• Main Authors: Peng Li (Author), Zhiyong Ji (Author), Erlei Zhi (Author), Yuxiang Zhang (Author), Sha Han (Author), Liangyu Zhao (Author), Ruhui Tian (Author), Huixing Chen (Author), Yuhua Huang (Author), Jing Zhang (Author), Huirong Chen (Author), Fujun Zhao (Author), Zhi Zhou (Author), Zheng Li (Author), Chencheng Yao (Author)
• Format: Book
• Published: BMC, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Non-obstructive azoospermia (NOA) is one of the most severe type in male infertility, and the genetic causes of NOA with meiotic arrest remain elusive. Methods Four Chinese families with NOA participated in the study. We performed whole-exome sequencing (WES) for the four NOA-aff...