Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2

Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2

Due to their system of annulated 6-5-5-6-membered rings, indenoindoles have sparked great interest for the design of ATP-competitive inhibitors of human CK2. In the present study, we prepared twenty-one indeno[1,2-b]indole derivatives, all of which were tested in vitro on human CK2. The indenoindolo...

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Main Authors: Faten Alchab (Author), Laurent Ettouati (Author), Zouhair Bouaziz (Author), Andre Bollacke (Author), Jean-Guy Delcros (Author), Christoph G.W. Gertzen (Author), Holger Gohlke (Author), Noël Pinaud (Author), Mathieu Marchivie (Author), Jean Guillon (Author), Bernard Fenet (Author), Joachim Jose (Author), Marc Le Borgne (Author)
Format: Book
Published: MDPI AG, 2015-06-01T00:00:00Z.
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