Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2

• 主要な著者: Faten Alchab (著者), Laurent Ettouati (著者), Zouhair Bouaziz (著者), Andre Bollacke (著者), Jean-Guy Delcros (著者), Christoph G.W. Gertzen (著者), Holger Gohlke (著者), Noël Pinaud (著者), Mathieu Marchivie (著者), Jean Guillon (著者), Bernard Fenet (著者), Joachim Jose (著者), Marc Le Borgne (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2015-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Due to their system of annulated 6-5-5-6-membered rings, indenoindoles have sparked great interest for the design of ATP-competitive inhibitors of human CK2. In the present study, we prepared twenty-one indeno[1,2-b]indole derivatives, all of which were tested in vitro on human CK2. The indenoindolo...