LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through the MEK/ERK signaling pathway

• Main Authors: Ziye Chen (Author), Lu Chen (Author), Bo Sun (Author), Dongming Liu (Author), Yuchao He (Author), Lisha Qi (Author), Guangtao Li (Author), Zhiqiang Han (Author), Linlin Zhan (Author), Su Zhang (Author), Keyun Zhu (Author), Yi Luo (Author), Liwei Chen (Author), Ning Zhang (Author), Hua Guo (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Adaptive rewiring of cancer energy metabolism has received increasing attention. By binding with LDLs, LDLRs make most of the circulating cholesterol available for cells to utilize. However, it remains unclear how LDLR works in HCC development by affecting cholesterol metabolism. Methods:...