Expansion of parasite-specific CD4+ and CD8+ T cells expressing IL-10 superfamily cytokine members and their regulation in human lymphatic filariasis.

• Main Authors: Rajamanickam Anuradha (Author), Parakkal Jovvian George (Author), Luke E Hanna (Author), Paul Kumaran (Author), Vedachalam Chandrasekaran (Author), Thomas B Nutman (Author), Subash Babu (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lymphatic filariasis (LF) is known to be associated with an increased production of IL-10. The role of the other IL-10 family members in the pathogenesis of infection and/or disease is not known.We examined the expression patterns of IL-10 family members--IL-19, IL-24 and IL-26 in LF. We demonstrate...