Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors

• Main Authors: Michele Malaguarnera (Author), Marta Llansola (Author), Tiziano Balzano (Author), Belén Gómez-Giménez (Author), Carles Antúnez-Muñoz (Author), Núria Martínez-Alarcón (Author), Rahebeh Mahdinia (Author), Vicente Felipo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Patients with liver cirrhosis may develop minimal hepatic encephalopathy (MHE) with mild cognitive impairment. Hyperammonemia is a main contributor to cognitive impairment in MHE, which is mediated by neuroinflammation. GABAergic neurotransmission is altered in hyperammonemic rats. We hypothesized t...