Ascorbic Acid Sensitizes Colorectal Carcinoma to the Cytotoxicity of Arsenic Trioxide via Promoting Reactive Oxygen Species-Dependent Apoptosis and Pyroptosis

Arsenic trioxide (ATO) is an effective therapeutic agent against acute promyelocytic leukemia (APL); however, its anti-tumor effect on solid tumors such as colorectal cancer (CRC) is still in debate. Ascorbic acid (AA) also produces a selective cytotoxic activity against tumor cells. Here, we exploi...

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Main Authors: Wei Tian (Author), Zhuo Wang (Author), Nan-nan Tang (Author), Jia-tong Li (Author), Yu Liu (Author), Wen-Feng Chu (Author), Bao-Feng Yang (Author)
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Publicado em: Frontiers Media S.A., 2020-02-01T00:00:00Z.
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