Ascorbic Acid Sensitizes Colorectal Carcinoma to the Cytotoxicity of Arsenic Trioxide via Promoting Reactive Oxygen Species-Dependent Apoptosis and Pyroptosis

• Egile Nagusiak: Wei Tian (Egilea), Zhuo Wang (Egilea), Nan-nan Tang (Egilea), Jia-tong Li (Egilea), Yu Liu (Egilea), Wen-Feng Chu (Egilea), Bao-Feng Yang (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Arsenic trioxide (ATO) is an effective therapeutic agent against acute promyelocytic leukemia (APL); however, its anti-tumor effect on solid tumors such as colorectal cancer (CRC) is still in debate. Ascorbic acid (AA) also produces a selective cytotoxic activity against tumor cells. Here, we exploi...