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α/β-Peptides as Nanomolar Triggers of Lipid Raft-Mediated Endocytosis through GM1 Ganglioside Recognition

Cell delivery of therapeutic macromolecules and nanoparticles is a critical drug development challenge. Translocation through lipid raft-mediated endocytic mechanisms is being sought, as it can avoid rapid lysosomal degradation. Here, we present a set of short α/β-peptide tags with high affinity to...

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Main Authors: Anasztázia Hetényi (Author), Enikő Szabó (Author), Norbert Imre (Author), Kaushik Nath Bhaumik (Author), Attila Tököli (Author), Tamás Füzesi (Author), Réka Hollandi (Author), Peter Horvath (Author), Ágnes Czibula (Author), Éva Monostori (Author), Mária A. Deli (Author), Tamás A. Martinek (Author)
Format: Book
Published: MDPI AG, 2022-03-01T00:00:00Z.
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Summary:Cell delivery of therapeutic macromolecules and nanoparticles is a critical drug development challenge. Translocation through lipid raft-mediated endocytic mechanisms is being sought, as it can avoid rapid lysosomal degradation. Here, we present a set of short α/β-peptide tags with high affinity to the lipid raft-associated ganglioside GM1. These sequences induce effective internalization of the attached immunoglobulin cargo. The structural requirements of the GM1-peptide interaction are presented, and the importance of the membrane components are shown. The results contribute to the development of a receptor-based cell delivery platform.
Item Description:10.3390/pharmaceutics14030580
1999-4923

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