Modelling Hydrocortisone Pharmacokinetics on a Subcutaneous Pulsatile Infusion Replacement Strategy in Patients with Adrenocortical Insufficiency

• Main Authors: Ioannis G. Violaris (Author), Konstantinos Kalafatakis (Author), Eder Zavala (Author), Ioannis G. Tsoulos (Author), Theodoros Lampros (Author), Stafford L. Lightman (Author), Markos G. Tsipouras (Author), Nikolaos Giannakeas (Author), Alexandros Tzallas (Author), Georgina M. Russell (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the context of glucocorticoid (GC) therapeutics, recent studies have utilised a subcutaneous hydrocortisone (HC) infusion pump programmed to deliver multiple HC pulses throughout the day, with the purpose of restoring normal circadian and ultradian GC rhythmicity. A key challenge for the advancem...