Effects of a reactive oxygen species generator, napabucasin (BBI608), on tolerability, safety, pharmacokinetics, and QT/QTc interval in healthy volunteers

• Main Authors: Naoto Noda (Author), Takeshi Takagaki (Author), Yasuhide Yodo (Author), Yuzo Horibuchi (Author), Shuichi Iino (Author), Shunji Matsuki (Author), Yoichiro Ogama (Author), Hiroyoshi Kakuyama (Author)
• Format: Book
• Published: Wiley, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract This study examined the safety, tolerability, and pharmacokinetics (PK) of napabucasin in healthy Asian and non‐Asian participants and investigated the potential for QT/QTc interval prolongation. This five‐part (A-E) study proceeded in a stepwise manner, unless stopping criteria were met. P...