Linear-like polypeptide-based micelle with pH-sensitive detachable PEG to deliver dimeric camptothecin for cancer therapy

• Main Authors: Ka Hong Wong (Author), Zhaopei Guo (Author), Di Jiang (Author), Xingzhi Zhou (Author), Lizhu Lin (Author), Denggao Zhao (Author), Meiwan Chen (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nano drug delivery systems have made significant progress in delivering anticancer drugs camptothecin (CPT). However, many challenges for CPT delivery remain, including low drug loading efficiency, premature drug leakage, and poor cellular internalization. Herein, we report a novel dual-sensitive po...