Case Report : Li-Fraumeni Syndrome with Central Nervous System Tumors in Two Siblings

• Main Authors: Zishi Fang (Author), Yan Su (Author), Hailang Sun (Author), Ming Ge (Author), Zhan Qi (Author), Chanjuan Hao (Author), Suyun Qian (Author), Xiaoli Ma (Author)
• Format: Book
• Published: BMC, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Li-Fraumeni syndrome (LFS) is a rare autosomal dominant cancer predisposition syndrome caused by germline TP53 gene mutations. It is characterized by high risk of early-onset cancer, and has been confirmed as associated with multiple tumors clinically. So pediatricians should be...