Generating CAR T cells from tumor-infiltrating lymphocytes

• Main Authors: Jane K. Mills (Author), Melissa A. Henderson (Author), Lauren Giuffrida (Author), Pasquale Petrone (Author), Jennifer A. Westwood (Author), Phillip K. Darcy (Author), Paul J. Neeson (Author), Michael H. Kershaw (Author), David E. Gyorki (Author)
• Format: Book
• Published: SAGE Publishing, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Tumor-infiltrating lymphocytes (TILs) and chimeric antigen receptor (CAR) T-cell therapies have demonstrated promising, though limited, efficacy against melanoma. Methods: We designed a model system to explore the efficacy of dual specific T cells derived from melanoma patient TILs by tr...