Generating CAR T cells from tumor-infiltrating lymphocytes

• मुख्य लेखकों: Jane K. Mills (लेखक), Melissa A. Henderson (लेखक), Lauren Giuffrida (लेखक), Pasquale Petrone (लेखक), Jennifer A. Westwood (लेखक), Phillip K. Darcy (लेखक), Paul J. Neeson (लेखक), Michael H. Kershaw (लेखक), David E. Gyorki (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: SAGE Publishing, 2021-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Background: Tumor-infiltrating lymphocytes (TILs) and chimeric antigen receptor (CAR) T-cell therapies have demonstrated promising, though limited, efficacy against melanoma. Methods: We designed a model system to explore the efficacy of dual specific T cells derived from melanoma patient TILs by tr...