The antitumor activity of CYB-L10, a human topoisomerase IB catalytic inhibitor

• Main Authors: Qian Yu (Author), Yu Chen (Author), Hui Yang (Author), Hong-Li Zhang (Author), Keli Agama (Author), Yves Pommier (Author), Lin-Kun An (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DNA topoisomerase IB (TOP1) is a validated target for discovery and development of antitumor agents. Four TOP1 poisons are clinically used for tumor treatment now. In spite of their effectiveness in solid tumors, these camptothecin (CPT) poisons suffer from many shortcomings. Therefore, many investi...